Rapid screening methods for universal binding peptide
aptamers against SARS-CoV-2 variant spikes, including omicron variants, and their application to diagnostic and therapeutic agents. | Research Square
https://www.researchsquare.com/article/rs-2609957/v2
The development of mRNA vaccines and oral drugs against SARS-CoV-2 has been useful in protecting against Covid-19 infection. Since then, however, many variants of delta and omicron
strains with enhanced infectivity and immune escape capacity have emerged.
A 7-amino acid random peptide ribosome display library screening system was used to perform a rapid in vitro screening of peptide aptamers that universally bind to the SARS-CoV-2
wild-type, delta, and Omicron variant BA.1, BA.2, and BA.5 spike RBD (Receptor Binding Domain).
Screening resulted in four peptide aptamers that showed positive binding reactions in ELISA.
Interestingly, Amino Acid Sequence Determination of the four clones predicted that three of the four clones contain 2 ~ 3 Cys residues in their sequences, forming a complex
higher-order structure with disulfide (S-S) bonds.
The 7-amino acid random peptide ribosome display library screening system allows for rapid in vitro screening of peptide aptamers that bind to other unknown emerging infectious
disease pathogens that may be pandemic in the future.
The peptide aptamers are as small as 30 amino acids and can be easily synthesized and purified as peptides or proteins, or simply used as mRNA drugs.
当社ジーントライの抗体様ペプチドアプタマースクリーニングシステムALPA-SSが、
最も先進的・実践的で､最速､最高精度で、非常に低コストでスクリーニング可能です。
そして､他社比較で､
・受託プロジェクト、
・契約プロジェクト、
を含めて、最短、低価格でご提供が可能です。
他社の見積もりをお見せいただければ､その価格より大幅な低価格でお見積もり可能です。
また、スクリーニングのスピード、品質、精度、において他社に負けることはございません。是非とも､お見積もりをご依頼下さい。
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Our ALPA screening system is the most advanced, practical, fastest, most accurate, and lowest cost screening
available, if compared to other companies.
We are able to provide you with the fastest and lowest price including
If you show us a quote from another company, we can provide you with a much lower
price.
In addition, our screening speed, quality, and accuracy are second to none.
Please contact us for a quote.
抗体様ペプチドアプタマーALPA;
ペプチド形状(7~12残基長)の次世代抗体！
Next generation antibodies in the form of peptides (7~12 residues long)!
↓↓↓↓↓↓↓↓↓↓↓↓↓↓↓↓
世界で､最も実用的､最速、低コストな次世代抗体開発ツールである
「抗体様ペプチドアプタマースクリーニングシステムALPA-SS」が完成しました。
抗体様ペプチドアプタマーALPAはペプチド合成可能な次世代抗体様薬です。
The "Antibody-like Peptide Aptamer Screening System" is the world's most practical, fastest, and lowest-cost next-generation antibody development tool.
Antibody-like Peptide Aptamer Screening System (ALPA-SS)
Also, ALPA is a next-generation antibody-like drug that can be synthesized by peptide synthesis, too. !!!
